Category : Research & Practice

The enormous surface area of the human intestinal barrier is key to maintaining a delicate physiological homeostasis. On one hand, it must be optimized for absorption of water and nutrients; on the other hand, it must act as a tight barrier against chemical and microbial challenges - all while protecting us from unnecessary reactions to compounds that are harmful to…

Megan Mouw
Megan Mouw holds a Bachelor of Science in microbiology from McGill University (Canada). Driven by her experiences at UCSF medical center in San Francisco, Megan is passionate about the role that the gut microbiota plays in maintaining health and wellness. She is currently perusing graduate studies in Microbiology and Environmental Toxicology at the University of California Santa Cruz and hopes to share her love of science through writing.

The enormous surface area of the human intestinal barrier is key to maintaining a delicate physiological homeostasis. On one hand, it must be optimized for absorption of water and nutrients; on the other hand, it must act as a tight barrier against chemical and microbial challenges - all while protecting us from unnecessary reactions to compounds that are harmful to…

Megan Mouw
Megan Mouw holds a Bachelor of Science in microbiology from McGill University (Canada). Driven by her experiences at UCSF medical center in San Francisco, Megan is passionate about the role that the gut microbiota plays in maintaining health and wellness. She is currently perusing graduate studies in Microbiology and Environmental Toxicology at the University of California Santa Cruz and hopes to share her love of science through writing.

Looking for a review that covers all the bases of probiotic health effects? A new, open access paper may serve that purpose. “Probiotics for human use” is a peer-reviewed paper published by the Nutrition Bulletin. This was a collaborative effort by experts in clinical effects (Prof. Dan Merenstein MD from Georgetown University, Claire Merrifield PhD from Imperial College London), fermented…

Mary Ellen Sanders
Mary Ellen Sanders is a consultant in the area of probiotic microbiology, with special expertise on paths to scientific substantiation of probiotic product label claims. Dr. Sanders served as the founding president of the International Scientific Association for Probiotics and Prebiotics (ISAPP) and is currently the organization’s Director of Scientific Affairs/ Executive Officer. This international, non-profit association of academic and industrial scientists is dedicated to advancing the science of probiotics and prebiotics (www.isapp.net). Through numerous written, oral and video pieces, including a website, www.usprobiotics.org, she strives to provide objective, evidence-based information on probiotics for consumers and professionals. Key activities include: Panels to determine GRAS status of probiotic strains ; member of the American Gastroenterological Association Scientific Advisory Board for AGA Center for Gut Microbiome Research and Education ; World Gastroenterology Organisation Committee preparing practice guidelines for the use of probiotics and prebiotics for GI indications (2008, 2011, 2014) ; working group convened by the FAO/WHO that developed guidelines for probiotics (2002).

Looking for a review that covers all the bases of probiotic health effects? A new, open access paper may serve that purpose. “Probiotics for human use” is a peer-reviewed paper published by the Nutrition Bulletin. This was a collaborative effort by experts in clinical effects (Prof. Dan Merenstein MD from Georgetown University, Claire Merrifield PhD from Imperial College London), fermented…

Mary Ellen Sanders
Mary Ellen Sanders is a consultant in the area of probiotic microbiology, with special expertise on paths to scientific substantiation of probiotic product label claims. Dr. Sanders served as the founding president of the International Scientific Association for Probiotics and Prebiotics (ISAPP) and is currently the organization’s Director of Scientific Affairs/ Executive Officer. This international, non-profit association of academic and industrial scientists is dedicated to advancing the science of probiotics and prebiotics (www.isapp.net). Through numerous written, oral and video pieces, including a website, www.usprobiotics.org, she strives to provide objective, evidence-based information on probiotics for consumers and professionals. Key activities include: Panels to determine GRAS status of probiotic strains ; member of the American Gastroenterological Association Scientific Advisory Board for AGA Center for Gut Microbiome Research and Education ; World Gastroenterology Organisation Committee preparing practice guidelines for the use of probiotics and prebiotics for GI indications (2008, 2011, 2014) ; working group convened by the FAO/WHO that developed guidelines for probiotics (2002).

Other than gut microbiota's well-known functions, which include nutrient metabolism and absorption, xenobiotic and drug metabolism, and immune development, its role in protecting against pathogens has been poorly characterized. Previous research has identified some microbiota-mediated colonization resistance mechanisms, while little is known about whether microbial metabolites may also limit pathogen colonization. A new study, led by Dr. Denise Monack from…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Other than gut microbiota's well-known functions, which include nutrient metabolism and absorption, xenobiotic and drug metabolism, and immune development, its role in protecting against pathogens has been poorly characterized. Previous research has identified some microbiota-mediated colonization resistance mechanisms, while little is known about whether microbial metabolites may also limit pathogen colonization. A new study, led by Dr. Denise Monack from…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

This post is a shortened version of the original article published in Science Trends on July 11, 2018. If – for whatever reason – a single toxic bacterial species – Clostridium difficile (C-diff) – has taken over your entire gut ecosystem, has banished many of the commensal gut bacteria needed for a healthy life, and does not respond any longer…

Paul Enck
Prof. Dr. Paul Enck, Director of Research, Dept. of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Germany. His main interests are gut functions in health and disease, including functional and inflammatory bowel disorders, the role of the gut microbiota, regulation of eating and food intake and its disorders, of nausea, vomiting and motion sickness, and the psychophysiology and neurobiology of the placebo response, with specific emphasis on age and gender contributions. He has published more than 170 original data paper in scientific, peer-reviewed journals, and more than 250 book chapters and review articles. He is board member/treasurer of the European Society of Neurogastroenterology and Motility and of the German Society of Neurogastroenterology and Motility, and has served as reviewer for many international journals and grant agencies.

This post is a shortened version of the original article published in Science Trends on July 11, 2018. If – for whatever reason – a single toxic bacterial species – Clostridium difficile (C-diff) – has taken over your entire gut ecosystem, has banished many of the commensal gut bacteria needed for a healthy life, and does not respond any longer…

Paul Enck
Prof. Dr. Paul Enck, Director of Research, Dept. of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Germany. His main interests are gut functions in health and disease, including functional and inflammatory bowel disorders, the role of the gut microbiota, regulation of eating and food intake and its disorders, of nausea, vomiting and motion sickness, and the psychophysiology and neurobiology of the placebo response, with specific emphasis on age and gender contributions. He has published more than 170 original data paper in scientific, peer-reviewed journals, and more than 250 book chapters and review articles. He is board member/treasurer of the European Society of Neurogastroenterology and Motility and of the German Society of Neurogastroenterology and Motility, and has served as reviewer for many international journals and grant agencies.

The gut microbiota's composition and activity can be modulated by both environmental and host-derived factors. Among them, the homeostatic functions of immunoglobulin A (IgA) on gastrointestinal commensal bacteria has recently been confirmed in humans with IgA deficiency. A new study, led by Dr. Keiichiro Suzuki from the Graduate School of Medicine at Kyoto University and RIKEN Yokohama Institute (Japan), has…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

The gut microbiota's composition and activity can be modulated by both environmental and host-derived factors. Among them, the homeostatic functions of immunoglobulin A (IgA) on gastrointestinal commensal bacteria has recently been confirmed in humans with IgA deficiency. A new study, led by Dr. Keiichiro Suzuki from the Graduate School of Medicine at Kyoto University and RIKEN Yokohama Institute (Japan), has…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

Surf the web and you’ll find many claims about probiotics, but many times what’s said isn’t based on fact. Sometimes this is because the author just doesn’t know the science. Sometimes it seems to be intentional, to promote some aspect of one product as better than other products. The International Scientific Association for Probiotics and Prebiotics (ISAPP) created an infographic…

Mary Ellen Sanders
Mary Ellen Sanders is a consultant in the area of probiotic microbiology, with special expertise on paths to scientific substantiation of probiotic product label claims. Dr. Sanders served as the founding president of the International Scientific Association for Probiotics and Prebiotics (ISAPP) and is currently the organization’s Director of Scientific Affairs/ Executive Officer. This international, non-profit association of academic and industrial scientists is dedicated to advancing the science of probiotics and prebiotics (www.isapp.net). Through numerous written, oral and video pieces, including a website, www.usprobiotics.org, she strives to provide objective, evidence-based information on probiotics for consumers and professionals. Key activities include: Panels to determine GRAS status of probiotic strains ; member of the American Gastroenterological Association Scientific Advisory Board for AGA Center for Gut Microbiome Research and Education ; World Gastroenterology Organisation Committee preparing practice guidelines for the use of probiotics and prebiotics for GI indications (2008, 2011, 2014) ; working group convened by the FAO/WHO that developed guidelines for probiotics (2002).

Surf the web and you’ll find many claims about probiotics, but many times what’s said isn’t based on fact. Sometimes this is because the author just doesn’t know the science. Sometimes it seems to be intentional, to promote some aspect of one product as better than other products. The International Scientific Association for Probiotics and Prebiotics (ISAPP) created an infographic…

Mary Ellen Sanders
Mary Ellen Sanders is a consultant in the area of probiotic microbiology, with special expertise on paths to scientific substantiation of probiotic product label claims. Dr. Sanders served as the founding president of the International Scientific Association for Probiotics and Prebiotics (ISAPP) and is currently the organization’s Director of Scientific Affairs/ Executive Officer. This international, non-profit association of academic and industrial scientists is dedicated to advancing the science of probiotics and prebiotics (www.isapp.net). Through numerous written, oral and video pieces, including a website, www.usprobiotics.org, she strives to provide objective, evidence-based information on probiotics for consumers and professionals. Key activities include: Panels to determine GRAS status of probiotic strains ; member of the American Gastroenterological Association Scientific Advisory Board for AGA Center for Gut Microbiome Research and Education ; World Gastroenterology Organisation Committee preparing practice guidelines for the use of probiotics and prebiotics for GI indications (2008, 2011, 2014) ; working group convened by the FAO/WHO that developed guidelines for probiotics (2002).

The prevalence of obesity and related metabolic conditions is increasing worldwide and has become a major public health issue. Recent research has highlighted the gut microbiome's contribution to the development of non-communicable diseases, although little is known about underlying mechanisms and causal relationships. A new study led by Prof. Harry Sokol, a gastroenterologist and researcher from the French National Institute…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

The prevalence of obesity and related metabolic conditions is increasing worldwide and has become a major public health issue. Recent research has highlighted the gut microbiome's contribution to the development of non-communicable diseases, although little is known about underlying mechanisms and causal relationships. A new study led by Prof. Harry Sokol, a gastroenterologist and researcher from the French National Institute…

Andreu Prados
Andreu Prados holds a Bachelor of Science Degree in Pharmacy & Human Nutrition and Dietetics. Science writer specialised in gut microbiota and probiotics, working also as lecturer and consultant in nutrition and healthcare. Follow Andreu on Twitter @andreuprados

The administration of broad-spectrum antibiotics is an important risk factor for Clostridium difficile infection (CDI) in the Western world. Recent research has suggested that probiotics may help reduce the incidence of C. difficile-associated diarrhea (CDAD) among children and adults in both hospital and outpatient settings. A new systematic review and meta-analysis, led by Dr. Bradley Johnston from Dealhousie University (Canada),…

Paul Enck
Prof. Dr. Paul Enck, Director of Research, Dept. of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Germany. His main interests are gut functions in health and disease, including functional and inflammatory bowel disorders, the role of the gut microbiota, regulation of eating and food intake and its disorders, of nausea, vomiting and motion sickness, and the psychophysiology and neurobiology of the placebo response, with specific emphasis on age and gender contributions. He has published more than 170 original data paper in scientific, peer-reviewed journals, and more than 250 book chapters and review articles. He is board member/treasurer of the European Society of Neurogastroenterology and Motility and of the German Society of Neurogastroenterology and Motility, and has served as reviewer for many international journals and grant agencies.

The administration of broad-spectrum antibiotics is an important risk factor for Clostridium difficile infection (CDI) in the Western world. Recent research has suggested that probiotics may help reduce the incidence of C. difficile-associated diarrhea (CDAD) among children and adults in both hospital and outpatient settings. A new systematic review and meta-analysis, led by Dr. Bradley Johnston from Dealhousie University (Canada),…

Paul Enck
Prof. Dr. Paul Enck, Director of Research, Dept. of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Germany. His main interests are gut functions in health and disease, including functional and inflammatory bowel disorders, the role of the gut microbiota, regulation of eating and food intake and its disorders, of nausea, vomiting and motion sickness, and the psychophysiology and neurobiology of the placebo response, with specific emphasis on age and gender contributions. He has published more than 170 original data paper in scientific, peer-reviewed journals, and more than 250 book chapters and review articles. He is board member/treasurer of the European Society of Neurogastroenterology and Motility and of the German Society of Neurogastroenterology and Motility, and has served as reviewer for many international journals and grant agencies.

Patients with gastrointestinal diseases often experience symptoms (diarrhea, constipation, abdominal pain, bloating) that worsen after a meal. They draw linkages between what they eat and negative consequences for their well-being. In an attempt to self-manage, patients often end up removing foods from their diet that are needed for nutritional health. They turn to their medical practitioners for information and support…

Andrea Hardy
Registered Dietitian, Andrea Hardy from Calgary, Canada specializes in gastrointestinal disorders and the gut microbiome. She is recognized as Canada’s gut health dietitian – educating health care professionals and the public on the pivotal role nutrition plays in gut health. You can find her at Ignite Nutrition, or on Twitter (@AndreaHardyRD).

Patients with gastrointestinal diseases often experience symptoms (diarrhea, constipation, abdominal pain, bloating) that worsen after a meal. They draw linkages between what they eat and negative consequences for their well-being. In an attempt to self-manage, patients often end up removing foods from their diet that are needed for nutritional health. They turn to their medical practitioners for information and support…

Andrea Hardy
Registered Dietitian, Andrea Hardy from Calgary, Canada specializes in gastrointestinal disorders and the gut microbiome. She is recognized as Canada’s gut health dietitian – educating health care professionals and the public on the pivotal role nutrition plays in gut health. You can find her at Ignite Nutrition, or on Twitter (@AndreaHardyRD).

On June 5-7, the International Scientific Association for Probiotics and Prebiotics (ISAPP) convened its annual meeting, for the first time in Asia. The program featured two days of open plenary sessions attended by 230 academic and industry scientists, health professionals, and regulatory representatives. A third day of discussion groups was held for invited experts and Industry Advisory Committee members, while…

Mary Ellen Sanders
Mary Ellen Sanders is a consultant in the area of probiotic microbiology, with special expertise on paths to scientific substantiation of probiotic product label claims. Dr. Sanders served as the founding president of the International Scientific Association for Probiotics and Prebiotics (ISAPP) and is currently the organization’s Director of Scientific Affairs/ Executive Officer. This international, non-profit association of academic and industrial scientists is dedicated to advancing the science of probiotics and prebiotics (www.isapp.net). Through numerous written, oral and video pieces, including a website, www.usprobiotics.org, she strives to provide objective, evidence-based information on probiotics for consumers and professionals. Key activities include: Panels to determine GRAS status of probiotic strains ; member of the American Gastroenterological Association Scientific Advisory Board for AGA Center for Gut Microbiome Research and Education ; World Gastroenterology Organisation Committee preparing practice guidelines for the use of probiotics and prebiotics for GI indications (2008, 2011, 2014) ; working group convened by the FAO/WHO that developed guidelines for probiotics (2002).

On June 5-7, the International Scientific Association for Probiotics and Prebiotics (ISAPP) convened its annual meeting, for the first time in Asia. The program featured two days of open plenary sessions attended by 230 academic and industry scientists, health professionals, and regulatory representatives. A third day of discussion groups was held for invited experts and Industry Advisory Committee members, while…

Mary Ellen Sanders
Mary Ellen Sanders is a consultant in the area of probiotic microbiology, with special expertise on paths to scientific substantiation of probiotic product label claims. Dr. Sanders served as the founding president of the International Scientific Association for Probiotics and Prebiotics (ISAPP) and is currently the organization’s Director of Scientific Affairs/ Executive Officer. This international, non-profit association of academic and industrial scientists is dedicated to advancing the science of probiotics and prebiotics (www.isapp.net). Through numerous written, oral and video pieces, including a website, www.usprobiotics.org, she strives to provide objective, evidence-based information on probiotics for consumers and professionals. Key activities include: Panels to determine GRAS status of probiotic strains ; member of the American Gastroenterological Association Scientific Advisory Board for AGA Center for Gut Microbiome Research and Education ; World Gastroenterology Organisation Committee preparing practice guidelines for the use of probiotics and prebiotics for GI indications (2008, 2011, 2014) ; working group convened by the FAO/WHO that developed guidelines for probiotics (2002).